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spr sensorgrams  (CH Instruments)

 
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    CH Instruments spr sensorgrams
    Experimentally measured binding properties of hit molecules. <t>SPR</t> <t>sensorgrams,</t> fragments (see Figure S2 for full spectra) of NMR spectra of fluorinated compounds (10 μM compound with 0 [black], 20 [red] μM protein), and chemical structures are shown. Solubility and aggregation of compounds as measured by DLS, as well as the set from which each compound was identified, are indicated.
    Spr Sensorgrams, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/spr sensorgrams/product/CH Instruments
    Average 90 stars, based on 1 article reviews
    spr sensorgrams - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities"

    Article Title: Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities

    Journal: Journal of Chemical Information and Modeling

    doi: 10.1021/acs.jcim.5c00588

    Experimentally measured binding properties of hit molecules. SPR sensorgrams, fragments (see Figure S2 for full spectra) of NMR spectra of fluorinated compounds (10 μM compound with 0 [black], 20 [red] μM protein), and chemical structures are shown. Solubility and aggregation of compounds as measured by DLS, as well as the set from which each compound was identified, are indicated.
    Figure Legend Snippet: Experimentally measured binding properties of hit molecules. SPR sensorgrams, fragments (see Figure S2 for full spectra) of NMR spectra of fluorinated compounds (10 μM compound with 0 [black], 20 [red] μM protein), and chemical structures are shown. Solubility and aggregation of compounds as measured by DLS, as well as the set from which each compound was identified, are indicated.

    Techniques Used: Binding Assay, Solubility



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    Experimentally measured binding properties of hit molecules. <t>SPR</t> <t>sensorgrams,</t> fragments (see Figure S2 for full spectra) of NMR spectra of fluorinated compounds (10 μM compound with 0 [black], 20 [red] μM protein), and chemical structures are shown. Solubility and aggregation of compounds as measured by DLS, as well as the set from which each compound was identified, are indicated.
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    spr sensorgram data  (Biacore)
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    Experimentally measured binding properties of hit molecules. <t>SPR</t> <t>sensorgrams,</t> fragments (see Figure S2 for full spectra) of NMR spectra of fluorinated compounds (10 μM compound with 0 [black], 20 [red] μM protein), and chemical structures are shown. Solubility and aggregation of compounds as measured by DLS, as well as the set from which each compound was identified, are indicated.
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    Image Search Results


    Experimentally measured binding properties of hit molecules. SPR sensorgrams, fragments (see Figure S2 for full spectra) of NMR spectra of fluorinated compounds (10 μM compound with 0 [black], 20 [red] μM protein), and chemical structures are shown. Solubility and aggregation of compounds as measured by DLS, as well as the set from which each compound was identified, are indicated.

    Journal: Journal of Chemical Information and Modeling

    Article Title: Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities

    doi: 10.1021/acs.jcim.5c00588

    Figure Lengend Snippet: Experimentally measured binding properties of hit molecules. SPR sensorgrams, fragments (see Figure S2 for full spectra) of NMR spectra of fluorinated compounds (10 μM compound with 0 [black], 20 [red] μM protein), and chemical structures are shown. Solubility and aggregation of compounds as measured by DLS, as well as the set from which each compound was identified, are indicated.

    Article Snippet: Eleven hit candidates were advanced to dose–response experiments, eight of which had measurable dissociation constant K D better than 250 μM and acceptable SPR sensorgrams (Chi 2 < 10% R max ; T ( K D ) > 1), with K D values ranging from 18 to 230 μM ( and Table S1 ).

    Techniques: Binding Assay, Solubility